Pharmacology & Mechanism of Action
SR-17018 is a biased agonist at the μ-opioid receptor (MOR).
🧬 How It Works
- G-protein biased - activates pain relief pathways
- β-arrestin sparing - reduces tolerance and side effects
- Partial agonist - ceiling effect limits overdose risk
📊 Key Differences from Traditional Opioids
| Traditional Opioids | SR-17018 |
|---|---|
| Full agonist + β-arrestin | Biased agonist |
| Rapid tolerance | Reduced tolerance |
| Respiratory depression | Ceiling effect |
🔬 Research Summary
- Animal studies show reduced tolerance development
- Less respiratory depression than morphine
- Maintains analgesic effects longer
💡 What This Means
SR-17018 may offer relief from withdrawal symptoms with fewer side effects and less risk of overdose compared to traditional opioids.
⚠️ Important Note
This is based on pre-clinical research. Human safety and efficacy data is limited. Always start with low doses and prioritize safety.